Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)

Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223).

Lymphocyte homeostasis is a central biological process that is tightly regulated. However, its molecular and cellular control is poorly understood. We show that aged mice deficient in lymphocyte activation gene 3 (LAG-3), an MHC class II binding CD4 homologue, have twice as many T cells as wild-type controls. CD4(+) and CD8(+) LAG-3-deficient T cells showed enhanced homeostatic expansion in lym...

Lymphocyte Activation Gene - 3 ( CD 223 ) Negative Regulation of T Cell Homeostasis

Negative Regulation of T Cell Homeostasis by Lymphocyte

Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo.

Lymphocyte activation gene-3 (LAG-3) is a CD4-related, activation-induced cell surface molecule that binds to MHC class II with high affinity. In this study, we used four experimental systems to reevaluate previous suggestions that LAG-3(-/-) mice had no T cell defect. First, LAG-3(-/-) T cells exhibited a delay in cell cycle arrest following in vivo stimulation with the superantigen staphyloco...

Population Following Antigen Activation In Regulates the Size of the Expanding T Cell Lymphocyte Activation Gene-3 (CD223)